A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron
; 83(2): 309-323, 2014 Jul 16.
Article
in En
| MEDLINE
| ID: mdl-24952961
ABSTRACT
To provide a temporal framework for the genoarchitecture of brain development, we generated in situ hybridization data for embryonic and postnatal mouse brain at seven developmental stages for â¼2,100 genes, which were processed with an automated informatics pipeline and manually annotated. This resource comprises 434,946 images, seven reference atlases, an ontogenetic ontology, and tools to explore coexpression of genes across neurodevelopment. Gene sets coinciding with developmental phenomena were identified. A temporal shift in the principles governing the molecular organization of the brain was detected, with transient neuromeric, plate-based organization of the brain present at E11.5 and E13.5. Finally, these data provided a transcription factor code that discriminates brain structures and identifies the developmental age of a tissue, providing a foundation for eventual genetic manipulation or tracking of specific brain structures over development. The resource is available as the Allen Developing Mouse Brain Atlas (http//developingmouse.brain-map.org).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Brain Mapping
/
Gene Expression Regulation, Developmental
/
Gene Expression Profiling
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Neuron
Journal subject:
NEUROLOGIA
Year:
2014
Document type:
Article
Affiliation country:
United States