Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative.

Brayden, David J; Walsh, Edwin

Brayden, David J; Walsh, Edwin.

Affiliation

Brayden DJ; School of Veterinary Medicine, Veterinary Sciences Centre and Conway Institute, University College Dublin, Room 214 Belfield, Dublin 4, Ireland, david.brayden@ucd.ie.

AAPS J ; 16(5): 1064-76, 2014 Sep.

Article in En | MEDLINE | ID: mdl-24961919

Subject(s)

Intestinal Absorption/drug effects; Intestinal Mucosa/drug effects; Undecylenic Acids/pharmacology; Animals; Caco-2 Cells; Cell Survival/drug effects; Chemistry, Pharmaceutical; Decanoic Acids/pharmacology; Dextrans/metabolism; Dose-Response Relationship, Drug; Electric Conductivity; Fluorescein-5-isothiocyanate/analogs & derivatives; Fluorescein-5-isothiocyanate/metabolism; Humans; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Kinetics; Mannitol/metabolism; Permeability; Rats; Tablets; Undecylenic Acids/chemistry; Undecylenic Acids/toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Undecylenic Acids / Intestinal Absorption / Intestinal Mucosa Limits: Animals / Humans Language: En Journal: AAPS J Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2014 Document type: Article Country of publication: United States

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