Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease.

Ueberham, Uwe; Rohn, Susanne; Ueberham, Elke; Wodischeck, Susanne; Hilbrich, Isabel; Holzer, Max; Brückner, Martina K; Gruschka, Hildegard; Arendt, Thomas

Ueberham, Uwe; Rohn, Susanne; Ueberham, Elke; Wodischeck, Susanne; Hilbrich, Isabel; Holzer, Max; Brückner, Martina K; Gruschka, Hildegard; Arendt, Thomas.

Affiliation

Ueberham U; Department for Molecular and Cellular Mechanisms of Neurodegeneration, University of Leipzig, Paul Flechsig Institute of Brain Research, Leipzig, Germany.

Neuropathol Appl Neurobiol ; 40(7): 815-32, 2014 Dec.

Article in En | MEDLINE | ID: mdl-24964035

Subject(s)

Alzheimer Disease/metabolism; Peptidylprolyl Isomerase/metabolism; Smad Proteins/metabolism; tau Proteins/metabolism; Aged; Aged, 80 and over; Female; Hippocampus/metabolism; Humans; Male; Middle Aged; NIMA-Interacting Peptidylprolyl Isomerase; Phosphorylation; Proteolysis

Key words

Alzheimer's disease; Pin1; Smad2; Smad3; neurodegeneration; neurofibrillary tangles; tau

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tau Proteins / Peptidylprolyl Isomerase / Smad Proteins / Alzheimer Disease Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Neuropathol Appl Neurobiol Year: 2014 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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