Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome.
Pathol Int
; 64(6): 283-8, 2014 Jun.
Article
in En
| MEDLINE
| ID: mdl-24965111
ABSTRACT
In this report, unique endocervical glandular lesions exhibiting gastric differentiation were examined in a patient with Peutz-Jeghers syndrome. The result of the human papillomavirus (HPV) in situ hybridization (ISH) for the hysterectomy specimens was negative, but they demonstrated a papillary mucinous adenocarcinoma at the proximal endocervix continuous to atypical lobular endocervical glandular hyperplasia. Both contained MUC6-positive neutral mucin in cytoplasm, and showed different immunoreactivity to p16, Ki-67, and p53. Moreover, they harbored the identical K-RAS gene mutation suggesting that there was a common origin. Somatic K-RAS mutation and defective function of p16 may have been involved in the tumorigenesis of these unusual mucinous neoplasms.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peutz-Jeghers Syndrome
/
Uterine Cervical Neoplasms
/
Proto-Oncogene Proteins
/
Adenocarcinoma, Mucinous
/
Ras Proteins
/
Neoplasm Proteins
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Pathol Int
Journal subject:
PATOLOGIA
Year:
2014
Document type:
Article
Affiliation country:
Japan