Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.

Friedrich, Corinna; Rinné, Susanne; Zumhagen, Sven; Kiper, Aytug K; Silbernagel, Nicole; Netter, Michael F; Stallmeyer, Birgit; Schulze-Bahr, Eric; Decher, Niels

Friedrich, Corinna; Rinné, Susanne; Zumhagen, Sven; Kiper, Aytug K; Silbernagel, Nicole; Netter, Michael F; Stallmeyer, Birgit; Schulze-Bahr, Eric; Decher, Niels.

Affiliation

Friedrich C; Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Münster, Germany.
Rinné S; Institute of Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany.
Zumhagen S; Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Münster, Germany.
Kiper AK; Institute of Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany.
Silbernagel N; Institute of Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany.
Netter MF; Institute of Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany.
Stallmeyer B; Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Münster, Germany.
Schulze-Bahr E; Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Münster, Germany.
Decher N; Institute of Physiology and Pathophysiology, Vegetative Physiology, University of Marburg, Marburg, Germany decher@staff.uni-marburg.de.

EMBO Mol Med ; 6(7): 937-51, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24972929

Subject(s)

Arrhythmias, Cardiac/genetics; Heart Conduction System/abnormalities; Mutation; Potassium Channels, Tandem Pore Domain/genetics; Potassium Channels, Tandem Pore Domain/metabolism; Ventricular Fibrillation/genetics; Amino Acid Sequence; Animals; Arrhythmias, Cardiac/complications; Arrhythmias, Cardiac/metabolism; Arrhythmias, Cardiac/pathology; Brugada Syndrome; Cardiac Conduction System Disease; Cell Line; Cohort Studies; Female; Genotype; Heart Conduction System/metabolism; Heart Conduction System/pathology; Humans; Male; Middle Aged; Molecular Sequence Data; Myocardium/metabolism; Myocardium/pathology; NAV1.5 Voltage-Gated Sodium Channel/analysis; NAV1.5 Voltage-Gated Sodium Channel/genetics; NAV1.5 Voltage-Gated Sodium Channel/metabolism; Potassium Channels, Tandem Pore Domain/analysis; Ventricular Fibrillation/complications; Ventricular Fibrillation/metabolism; Ventricular Fibrillation/pathology; Xenopus

Key words

K2P channels; SCN5A; arrhythmia; progressive cardiac conduction disorder

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arrhythmias, Cardiac / Ventricular Fibrillation / Potassium Channels, Tandem Pore Domain / Heart Conduction System / Mutation Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: EMBO Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2014 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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