Design, synthesis and biological evaluation of mitochondria targeting theranostic agents.

Wu, Song; Cao, Qizhen; Wang, Xiaolin; Cheng, Kai; Cheng, Zhen

Wu, Song; Cao, Qizhen; Wang, Xiaolin; Cheng, Kai; Cheng, Zhen.

Affiliation

Wu S; Molecular Imaging Program at Stanford (MIPS), Bio-X Program, Department of Radiology, Stanford University, California, 94305-5344, USA. zcheng@stanford.edu.

Chem Commun (Camb) ; 50(64): 8919-22, 2014 Aug 18.

Article in En | MEDLINE | ID: mdl-24976119

ABSTRACT

ABSTRACT

Dual mitochondria targeting fluorescent F16-TPP analogues were designed and synthesized. Uptake and cytotoxicity studies indicate that FF16 and FF16-TPP, two compounds discovered in this study, are promising mitochondria targeting theranostic agents.

Subject(s)

Antineoplastic Agents; Indoles; Mitochondria/metabolism; Onium Compounds; Organophosphorus Compounds; Pyridinium Compounds; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Cell Line, Tumor; Cell Proliferation/drug effects; Drug Design; Humans; Indoles/chemical synthesis; Indoles/pharmacology; Indoles/therapeutic use; Onium Compounds/chemical synthesis; Onium Compounds/pharmacology; Onium Compounds/therapeutic use; Optical Imaging; Organophosphorus Compounds/chemical synthesis; Organophosphorus Compounds/pharmacology; Organophosphorus Compounds/therapeutic use; Pyridinium Compounds/chemical synthesis; Pyridinium Compounds/pharmacology; Pyridinium Compounds/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Onium Compounds / Organophosphorus Compounds / Pyridinium Compounds / Indoles / Mitochondria / Antineoplastic Agents Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country: United States

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