Characterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6.

Singh, Shanteri; Nandurkar, Nitin S; Thorson, Jon S

Singh, Shanteri; Nandurkar, Nitin S; Thorson, Jon S.

Affiliation

Singh S; Center for Pharmaceutical Research and Innovation, Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536 (USA). ssingh555@uky.edu.

Chembiochem ; 15(10): 1418-21, 2014 Jul 07.

Article in En | MEDLINE | ID: mdl-24978950

Subject(s)

Bacteria/enzymology; Methyltransferases/metabolism; Resorcinols/metabolism; Bacteria/chemistry; Bacteria/metabolism; Hydroxylation; Kinetics; Methylation; Models, Molecular; Polyketide Synthases/metabolism; Protein Structure, Tertiary; S-Adenosylmethionine/metabolism; Streptomyces/chemistry; Streptomyces/enzymology; Streptomyces/metabolism; Substrate Specificity

Key words

AdoMet; S-adenosylmethionine; acyl carrier proteins; iterative PKSs; orsellinic acid; polyketides

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Resorcinols / Bacteria / Methyltransferases Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2014 Document type: Article Country of publication: Germany

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