Zebrafish as a new model for phenotype-based screening of positive inotropic agents.

Tang, Chunlei; Xie, Desheng; Feng, Bainian

Tang, Chunlei; Xie, Desheng; Feng, Bainian.

Affiliation

Tang C; School of Pharmaceutical Science, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, China.

Chem Biol Drug Des ; 85(3): 253-8, 2015 Mar.

Article in En | MEDLINE | ID: mdl-24990095

Subject(s)

Cardiotonic Agents/therapeutic use; Digoxin/therapeutic use; Heart Failure/drug therapy; Animals; Blood Pressure/drug effects; Cardiotonic Agents/chemistry; Cardiotonic Agents/pharmacology; Digoxin/chemistry; Digoxin/pharmacology; Disease Models, Animal; Embryo, Nonmammalian/drug effects; Embryo, Nonmammalian/physiology; Heart/drug effects; Heart/physiology; Heart Failure/chemically induced; Heart Rate/drug effects; Male; Myocardium/pathology; Phenotype; Rats; Rats, Sprague-Dawley; Terfenadine/toxicity; Zebrafish/growth & development

Key words

heart failure; phenotype-based; positive inotropic agent; zebrafish

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiotonic Agents / Digoxin / Heart Failure Type of study: Diagnostic_studies / Screening_studies Limits: Animals Language: En Journal: Chem Biol Drug Des Journal subject: BIOQUIMICA / FARMACIA / FARMACOLOGIA Year: 2015 Document type: Article Affiliation country: China Country of publication: United kingdom

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