Perioperative pharmacological management of pulmonary hypertensive crisis during congenital heart surgery.
Pulm Circ
; 4(1): 10-24, 2014 Mar.
Article
in En
| MEDLINE
| ID: mdl-25006417
ABSTRACT
Pulmonary hypertensive crisis is an important cause of morbidity and mortality in patients with pulmonary arterial hypertension secondary to congenital heart disease (PAH-CHD) who require cardiac surgery. At present, prevention and management of perioperative pulmonary hypertensive crisis is aimed at optimizing cardiopulmonary interactions by targeting prostacyclin, endothelin, and nitric oxide signaling pathways within the pulmonary circulation with various pharmacological agents. This review is aimed at familiarizing the practitioner with the current pharmacological treatment for dealing with perioperative pulmonary hypertensive crisis in PAH-CHD patients. Given the life-threatening complications associated with pulmonary hypertensive crisis, proper perioperative planning can help anticipate cardiopulmonary complications and optimize surgical outcomes in this patient population.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Pulm Circ
Year:
2014
Document type:
Article
Affiliation country:
United States