Acanthosis nigricans, vitamin D, and insulin resistance in obese children and adolescents.
J Pediatr Endocrinol Metab
; 27(11-12): 1107-11, 2014 Nov.
Article
in En
| MEDLINE
| ID: mdl-25010776
ABSTRACT
OBJECTIVES:
The aim of this study is to identify factors accounting for the variation in 25-hydroxyvitamin D levels in a pediatric obese population. PATIENTS ANDMETHODS:
One hundred and forty-nine obese children and adolescents (BMI ≥95th percentile) were evaluated in a pediatric endocrine office. Acanthosis nigricans (AN) skin lesions were rated on a 4-point scale.RESULTS:
The 25-hydroxyvitamin D levels were significantly different between those without AN and those with any severity of AN (p=<0.001). Insulin levels were only significantly different between those with no and severe AN (p=0.007). A general linear model showed that month of visit predicted 19.0% of the variation and AN an additional 2.2%. When AN was dropped from the full model, log-transformed HOMA-IR remained insignificant (p=0.164).CONCLUSIONS:
Season of evaluation was the main determinant of 25-hydroxyvitamin D levels. Severity of AN was a stronger predictor of 25-hydroxyvitamin D level variation than the measure of insulin resistance HOMA-IR.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vitamin D
/
Vitamins
/
Insulin Resistance
/
Acanthosis Nigricans
/
Insulin
/
Obesity
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Pediatr Endocrinol Metab
Journal subject:
ENDOCRINOLOGIA
/
PEDIATRIA
Year:
2014
Document type:
Article