Acanthosis nigricans, vitamin D, and insulin resistance in obese children and adolescents.

ABSTRACT

OBJECTIVES: The aim of this study is to identify factors accounting for the variation in 25-hydroxyvitamin D levels in a pediatric obese population. PATIENTS AND METHODS: One hundred and forty-nine obese children and adolescents (BMI ≥95th percentile) were evaluated in a pediatric endocrine office. Acanthosis nigricans (AN) skin lesions were rated on a 4-point scale. RESULTS: The 25-hydroxyvitamin D levels were significantly different between those without AN and those with any severity of AN (p=<0.001). Insulin levels were only significantly different between those with no and severe AN (p=0.007). A general linear model showed that month of visit predicted 19.0% of the variation and AN an additional 2.2%. When AN was dropped from the full model, log-transformed HOMA-IR remained insignificant (p=0.164). CONCLUSIONS: Season of evaluation was the main determinant of 25-hydroxyvitamin D levels. Severity of AN was a stronger predictor of 25-hydroxyvitamin D level variation than the measure of insulin resistance HOMA-IR.