Malarial pigment hemozoin impairs chemotactic motility and transendothelial migration of monocytes via 4-hydroxynonenal.

Skorokhod, Oleksii A; Barrera, Valentina; Heller, Regine; Carta, Franco; Turrini, Franco; Arese, Paolo; Schwarzer, Evelin

Skorokhod, Oleksii A; Barrera, Valentina; Heller, Regine; Carta, Franco; Turrini, Franco; Arese, Paolo; Schwarzer, Evelin.

Affiliation

Skorokhod OA; Department of Oncology, University of Torino, 10126 Torino, Italy.
Barrera V; Department of Oncology, University of Torino, 10126 Torino, Italy.
Heller R; Institute for Molecular Cell Biology, Center for Molecular Biomedicine, Friedrich Schiller University of Jena, 07745 Jena, Germany.
Carta F; Nurex srl, 07100 Sassari, Italy.
Turrini F; Department of Oncology, University of Torino, 10126 Torino, Italy.
Arese P; Department of Oncology, University of Torino, 10126 Torino, Italy.
Schwarzer E; Department of Oncology, University of Torino, 10126 Torino, Italy. Electronic address: evelin.schwarzer@unito.it.

Free Radic Biol Med ; 75: 210-21, 2014 Oct.

Article in En | MEDLINE | ID: mdl-25017964

Subject(s)

Aldehydes/metabolism; Cell Migration Inhibition/drug effects; Hemeproteins/pharmacology; Leukocytes, Mononuclear/metabolism; Transendothelial and Transepithelial Migration/drug effects; Actins/metabolism; Cells, Cultured; Chemokine CCL2/pharmacology; Chemotaxis/drug effects; Cytoskeleton/metabolism; Human Umbilical Vein Endothelial Cells; Humans; Malaria, Falciparum/immunology; Malaria, Falciparum/parasitology; Microfilament Proteins/metabolism; N-Formylmethionine Leucyl-Phenylalanine/pharmacology; Phagocytosis/physiology; Pigments, Biological/pharmacology; Plasmodium falciparum/enzymology; Plasmodium falciparum/immunology; Tumor Necrosis Factor-alpha/pharmacology

Key words

4-Hydroxynonenal; Actin; Coronin; Free radicals; Hemozoin; Lipoperoxidation; Malaria; Migration; Monocyte

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Migration Inhibition / Leukocytes, Mononuclear / Aldehydes / Transendothelial and Transepithelial Migration / Hemeproteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2014 Document type: Article Affiliation country: Italy Country of publication: United States

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