Amyloidosis/drug therapy; Indoles/pharmacology; Neuroprotective Agents/pharmacology; RNA, Messenger/genetics; Ubiquitinated Proteins/genetics; gamma-Synuclein/genetics; Administration, Oral; Amyloidosis/genetics; Amyloidosis/metabolism; Amyloidosis/pathology; Animals; Brain/drug effects; Brain/metabolism; Brain/pathology; Disease Models, Animal; Flocculation; Gene Expression; Longevity/drug effects; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Targeted Therapy; RNA, Messenger/metabolism; Solubility; Spinal Cord/drug effects; Spinal Cord/metabolism; Spinal Cord/pathology; Ubiquitinated Proteins/antagonists & inhibitors; Ubiquitinated Proteins/metabolism; Ubiquitination; gamma-Synuclein/metabolism

dimebon; neurodegeneration; neuroprotection; protein aggregation; transgenic models