Cytokines secreted by bone marrow stromal cells protect c-KIT mutant AML cells from c-KIT inhibitor-induced apoptosis.

Gordon, P M; Dias, Stuart; Williams, D A

Gordon, P M; Dias, Stuart; Williams, D A.

Affiliation

Gordon PM; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School and Harvard Stem Cell Institute, Boston, MA, USA.
Dias S; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School and Harvard Stem Cell Institute, Boston, MA, USA.
Williams DA; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School and Harvard Stem Cell Institute, Boston, MA, USA.

Leukemia ; 28(11): 2257-60, 2014 Nov.

Article in En | MEDLINE | ID: mdl-25030047

Subject(s)

Apoptosis/drug effects; Cytokines/metabolism; Leukemia, Myeloid, Acute/drug therapy; Leukemia, Myeloid, Acute/genetics; Mesenchymal Stem Cells/cytology; Proto-Oncogene Proteins c-kit/antagonists & inhibitors; Proto-Oncogene Proteins c-kit/genetics; Drug Resistance, Neoplasm; Humans; Leukemia, Myeloid, Acute/pathology; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Cytokines / Apoptosis / Proto-Oncogene Proteins c-kit / Mesenchymal Stem Cells Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2014 Document type: Article Affiliation country: United States Country of publication: United kingdom

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