Describing the potential crossreactome between mumps virus and spermatogenesis-associated proteins.
Endocr Metab Immune Disord Drug Targets
; 14(3): 218-25, 2014.
Article
in En
| MEDLINE
| ID: mdl-25030806
ABSTRACT
This study documents that mumps virus shares several peptide sequences with human proteins that, when altered, may be involved in oligospermia/azoospermia, sterility and testicular atrophy. Examples are sperm flagellar protein 2 and spermatogenesis and centriole-associated protein 1. The data invite to further investigate crossreactivity as a potential mechanism linking anti-mumps immune responses, alterations of spermatogenesis-associated antigens and male fertility disorders.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spermatogenesis
/
Proteome
/
Seminal Plasma Proteins
/
Mumps virus
/
Antigens, Viral
Type of study:
Risk_factors_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Endocr Metab Immune Disord Drug Targets
Journal subject:
ALERGIA E IMUNOLOGIA
/
ENDOCRINOLOGIA
/
METABOLISMO
/
TERAPIA POR MEDICAMENTOS
Year:
2014
Document type:
Article
Affiliation country:
Italy