Resistance of cytolytic lymphocytes to perforin-mediated killing. Murine cytotoxic T lymphocytes and human natural killer cells do not contain functional soluble homologous restriction factor or other specific soluble protective factors.

Jiang, S; Persechini, P M; Perussia, B; Young, J D

Jiang, S; Persechini, P M; Perussia, B; Young, J D.

Affiliation

Jiang S; Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York 10021.

J Immunol ; 143(5): 1453-60, 1989 Sep 01.

Article in En | MEDLINE | ID: mdl-2503557

Subject(s)

Blood Proteins/physiology; CD59 Antigens; Carrier Proteins; Cytotoxicity, Immunologic; Killer Cells, Natural/immunology; Membrane Glycoproteins; Membrane Proteins/physiology; T-Lymphocytes, Cytotoxic/immunology; Animals; Binding, Competitive; Calcium/pharmacology; Cell Fractionation; Cell Line; Complement System Proteins/physiology; Edetic Acid/pharmacology; Hemolysis; Hot Temperature; Humans; Immunity, Innate; Killer Cells, Natural/analysis; Membrane Proteins/antagonists & inhibitors; Mice; Papain; Perforin; Pore Forming Cytotoxic Proteins; Solubility; T-Lymphocytes, Cytotoxic/analysis; Trypsin

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Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Blood Proteins / Killer Cells, Natural / T-Lymphocytes, Cytotoxic / Carrier Proteins / CD59 Antigens / Cytotoxicity, Immunologic / Membrane Proteins Limits: Animals / Humans Language: En Journal: J Immunol Year: 1989 Document type: Article

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