Targeting the immune system to treat hypertension: where are we?
Curr Opin Nephrol Hypertens
; 23(5): 473-9, 2014 Sep.
Article
in En
| MEDLINE
| ID: mdl-25036747
ABSTRACT
PURPOSE OF REVIEW Research over the past decade has significantly deepened our understanding of mechanisms that drive the development of hypertension. In particular, a novel paradigm of inflammation as a common mediator of cardiovascular and kidney disease has emerged. This review will summarize the role of the immune system in cardiovascular disease, explore some of the most promising new therapeutic directions and consider their potential as new treatments for hypertension. RECENT FINDINGS:
Recent data continue to demonstrate that targeting the immune system can prevent hypertension in a variety of experimental models. Tempering the enthusiasm for a long-awaited new approach to treating hypertension is decades of clinical data, showing that classic immunosuppression regimens are associated with significant side-effects - including cardiovascular disease - that effectively preclude their use in the setting of chronic hypertension. New, more specific therapies are being developed that target cytokines including IL-17, IL-6 and TNFα.SUMMARY:
Preclinical data convincingly demonstrate a key role for the immune system and specific cytokine mediators. Several biotherapeutics targeting these pathways are on the market and more are in development. Side-effects, however, continue to resemble those of classic immunosuppressants, highlighting the challenge of translating these research advances into new therapies for hypertension. VIDEO ABSTRACT http//links.lww.com/CONH/A9.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Pressure
/
Hypertension
/
Immune System
/
Immunosuppressive Agents
/
Antihypertensive Agents
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Nephrol Hypertens
Journal subject:
ANGIOLOGIA
/
NEFROLOGIA
Year:
2014
Document type:
Article
Affiliation country:
United States