Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts.

Amend, Sarah R; Uluckan, Ozge; Hurchla, Michelle; Leib, Daniel; Novack, Deborah Veis; Silva, Matthew; Frazier, William; Weilbaecher, Katherine N

Amend, Sarah R; Uluckan, Ozge; Hurchla, Michelle; Leib, Daniel; Novack, Deborah Veis; Silva, Matthew; Frazier, William; Weilbaecher, Katherine N.

Affiliation

Amend SR; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

J Bone Miner Res ; 30(1): 106-15, 2015 Jan.

Article in En | MEDLINE | ID: mdl-25042340

Subject(s)

Bone Matrix/metabolism; Nitric Oxide/metabolism; Osteoclasts/metabolism; Signal Transduction/physiology; Thrombospondin 1/metabolism; Animals; Bone Matrix/cytology; Cell Differentiation/physiology; Gene Expression Regulation, Enzymologic/genetics; Mice; Mice, Knockout; Nitric Oxide/genetics; Nitric Oxide Synthase Type II/biosynthesis; Nitric Oxide Synthase Type II/genetics; Osteoclasts/cytology; Thrombospondin 1/genetics

Key words

BIOMECHANICS; MOLECULAR PATHWAYS - REMODELING; NON-COLLAGENOUS PROTEINS; OSTEOCLASTS

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Bone Matrix / Signal Transduction / Thrombospondin 1 / Nitric Oxide Limits: Animals Language: En Journal: J Bone Miner Res Journal subject: METABOLISMO / ORTOPEDIA Year: 2015 Document type: Article Affiliation country: United States Country of publication: United States

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