Simultaneous determination of atropine, scopolamine, and anisodamine from Hyoscyamus niger L. in rat plasma by high-performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetics study.

Zhang, Peiting; Li, Yemeng; Liu, Guanghui; Sun, Xiuman; Zhou, Yuting; Deng, Xuejiao; Liao, Qiongfeng; Xie, Zhiyong

Zhang, Peiting; Li, Yemeng; Liu, Guanghui; Sun, Xiuman; Zhou, Yuting; Deng, Xuejiao; Liao, Qiongfeng; Xie, Zhiyong.

Affiliation

Zhang P; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

J Sep Sci ; 37(19): 2664-74, 2014 Oct.

Article in En | MEDLINE | ID: mdl-25044356

Subject(s)

Atropine/blood; Atropine/pharmacokinetics; Hyoscyamus/chemistry; Scopolamine/blood; Scopolamine/pharmacokinetics; Solanaceous Alkaloids/blood; Solanaceous Alkaloids/pharmacokinetics; Animals; Chromatography, High Pressure Liquid; Male; Plant Extracts/blood; Plant Extracts/pharmacokinetics; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

Key words

Antispasmodic agent; Hyoscyamus niger L; Pharmacokinetics; Tropane alkaloids

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Atropine / Scopolamine / Solanaceous Alkaloids / Hyoscyamus Limits: Animals Language: En Journal: J Sep Sci Year: 2014 Document type: Article Affiliation country: China Country of publication: Germany

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