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Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.
Edupuganti, Ramakrishna; Wang, Qiantao; Tavares, Clint D J; Chitjian, Catrina A; Bachman, James L; Ren, Pengyu; Anslyn, Eric V; Dalby, Kevin N.
Affiliation
  • Edupuganti R; Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, TX 78712, USA; Department of Chemistry, The University of Texas at Austin, TX 78712, USA.
  • Wang Q; Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, TX 78712, USA; Department of Biomedical Engineering, Cockrell School of Engineering, College of Engineering, The University of Texas at Austin, TX 78712, USA.
  • Tavares CD; Graduate Program in Cell and Molecular Biology, The University of Texas at Austin, TX 78712, USA.
  • Chitjian CA; Graduate Program in Cell and Molecular Biology, The University of Texas at Austin, TX 78712, USA.
  • Bachman JL; Department of Chemistry, The University of Texas at Austin, TX 78712, USA.
  • Ren P; Department of Biomedical Engineering, Cockrell School of Engineering, College of Engineering, The University of Texas at Austin, TX 78712, USA.
  • Anslyn EV; Department of Chemistry, The University of Texas at Austin, TX 78712, USA. Electronic address: anslyn@austin.utexas.edu.
  • Dalby KN; Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, TX 78712, USA; Graduate Program in Cell and Molecular Biology, The University of Texas at Austin, TX 78712, USA. Electronic address: dalby@austin.utexas.edu.
Bioorg Med Chem ; 22(17): 4910-6, 2014 Sep 01.
Article in En | MEDLINE | ID: mdl-25047940

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidinones / Protein Kinase Inhibitors / Elongation Factor 2 Kinase Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidinones / Protein Kinase Inhibitors / Elongation Factor 2 Kinase Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United kingdom