Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs.

Matok, Ilan; Clark, Shannon; Caritis, Steve; Miodovnik, Menachem; Umans, Jason G; Hankins, Gary; Mattison, Donald R; Koren, Gideon

Matok, Ilan; Clark, Shannon; Caritis, Steve; Miodovnik, Menachem; Umans, Jason G; Hankins, Gary; Mattison, Donald R; Koren, Gideon.

Affiliation

Matok I; Motherisk Program, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Division of Clinical Pharmacy, Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

J Clin Pharmacol ; 54(12): 1429-33, 2014 Dec.

Article in En | MEDLINE | ID: mdl-25052410

Subject(s)

Antiemetics/therapeutic use; Dicyclomine/therapeutic use; Doxylamine/therapeutic use; Morning Sickness/drug therapy; Prodrugs/therapeutic use; Pyridoxine/therapeutic use; Antiemetics/blood; Antiemetics/pharmacokinetics; Delayed-Action Preparations; Dicyclomine/blood; Dicyclomine/pharmacokinetics; Double-Blind Method; Doxylamine/blood; Doxylamine/pharmacokinetics; Drug Combinations; Female; Humans; Morning Sickness/metabolism; Pregnancy; Prodrugs/pharmacokinetics; Pyridoxal/blood; Pyridoxal Phosphate/blood; Pyridoxine/blood; Pyridoxine/pharmacokinetics

Key words

morning sickness; nausea and vomiting of pregnancy; prodrug; pyridoxine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridoxine / Prodrugs / Morning Sickness / Dicyclomine / Doxylamine / Antiemetics Type of study: Clinical_trials Limits: Female / Humans / Pregnancy Language: En Journal: J Clin Pharmacol Year: 2014 Document type: Article Affiliation country: Israel Country of publication: United kingdom

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