Evaluation in rats of the somnogenic, pyrogenic, and central nervous system depressant effects of muramyl dipeptide.
Psychopharmacology (Berl)
; 99(1): 103-8, 1989.
Article
in En
| MEDLINE
| ID: mdl-2506595
ABSTRACT
Muramyl dipeptide increased sleep during the dark-phase, but not the light-phase of the rats' sleep-awake cycle. This circadian variation may be due to the inability of MDP to increase sleep over the high baseline levels of sleep that occur during the light-phase. However, MDP was pyrogenic during the light-phase, indicating it was pharmacologically active. In the dark-phase, MDP was not pyrogenic, but when compared to concurrent vehicle-treated rats, rats treated with MDP did not demonstrate as great a fall in body temperature. At approximately equisomnogenic doses, MDP produced less potentiation of ethanol-induced loss of righting reflex than triazolam, indicating it produces less non-specific central nervous system depressant effects. These data indicate the possibility of a new generation of hypnotic agents derived from muramyl peptides.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sleep
/
Body Temperature
/
Central Nervous System Depressants
/
Acetylmuramyl-Alanyl-Isoglutamine
Limits:
Animals
Language:
En
Journal:
Psychopharmacology (Berl)
Year:
1989
Document type:
Article