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One-pot oxidation and rearrangement of propargylamines and in situ pyrazole synthesis.
Chen, Jinshan; Properzi, Roberta; Uccello, Daniel P; Young, Jennifer A; Dushin, Russell G; Starr, Jeremy T.
Affiliation
  • Chen J; Pfizer Worldwide R&D, Eastern Point Road, Groton, Connecticut 06340, United States.
Org Lett ; 16(16): 4146-9, 2014 Aug 15.
Article in En | MEDLINE | ID: mdl-25069029
Reported here are procedures for a one-pot oxidation and rearrangement of propargylamines to synthesize enaminones, with supporting mechanistic studies. Also reported are the extended one-pot syntheses of pyrazoles, including celecoxib and various heterocyclic compounds.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pargyline / Propylamines / Pyrazoles / Sulfonamides Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pargyline / Propylamines / Pyrazoles / Sulfonamides Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States