Investigating the protective effect of lithium against high glucose-induced neurotoxicity in PC12 cells: involvements of ROS, JNK and P38 MAPKs, and apoptotic mitochondria pathway.

Aminzadeh, A; Dehpour, A R; Safa, M; Mirzamohammadi, S; Sharifi, A M

Aminzadeh, A; Dehpour, A R; Safa, M; Mirzamohammadi, S; Sharifi, A M.

Affiliation

Aminzadeh A; Razi Drug Research Center and Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Cell Mol Neurobiol ; 34(8): 1143-50, 2014 Nov.

Article in En | MEDLINE | ID: mdl-25073869

Subject(s)

Apoptosis/drug effects; Glucose/toxicity; Lithium/pharmacology; MAP Kinase Signaling System/drug effects; Mitochondria/metabolism; Neuroprotective Agents/pharmacology; Neurotoxins/toxicity; Reactive Oxygen Species/metabolism; Animals; Caspase 3/metabolism; Cell Survival/drug effects; Enzyme Activation/drug effects; Intracellular Space/drug effects; Intracellular Space/metabolism; JNK Mitogen-Activated Protein Kinases/metabolism; Lipid Peroxidation/drug effects; Mitochondria/drug effects; PC12 Cells; Phosphorylation/drug effects; Rats; Superoxide Dismutase/metabolism; bcl-2-Associated X Protein/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reactive Oxygen Species / Apoptosis / Neuroprotective Agents / MAP Kinase Signaling System / Glucose / Lithium / Mitochondria / Neurotoxins Limits: Animals Language: En Journal: Cell Mol Neurobiol Year: 2014 Document type: Article Affiliation country: Iran Country of publication: United States

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