SOX18 expression predicts response to platinum-based chemotherapy in ovarian cancer.
Anticancer Res
; 34(8): 4029-37, 2014 Aug.
Article
in En
| MEDLINE
| ID: mdl-25075026
ABSTRACT
BACKGROUND:
SOX18 is a transcription factor known to be involved in blood and lymphatic vessel, hair follicle development, and wound healing processes. In addition, it has been reported that SOX18 may influence cancer growth. The role of SOX18 expression in ovarian cancer (OC) has not been determined. MATERIALS ANDMETHODS:
SOX18 expression was assessed in 85 OC cases using immunohistochemical methods and in ovarian cancer cell lines on the mRNA and protein level.RESULTS:
SOX18 was expressed in cancer cell nuclei as well as the cytoplasm. Higher nuclear SOX18 expression was associated with presence of residual disease following surgical treatment (p=0.0158) and advanced disease stage (p=0.0056). Univariate survival analysis revealed that high SOX18 (p=0.0125) expression, presence of residual disease (p<0.0001) and advanced disease stage (p<0.0324) predicted poor patient outcome.CONCLUSION:
SOX18 may be a new predictive marker for OC.Key words
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
SOXF Transcription Factors
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Anticancer Res
Year:
2014
Document type:
Article
Affiliation country:
Poland