Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies.
Adv Drug Deliv Rev
; 76: 98-115, 2014 Sep 30.
Article
in En
| MEDLINE
| ID: mdl-25078721
ABSTRACT
The vast majority of malignant gliomas relapse after surgery and standard radio-chemotherapy. Novel molecular and cellular therapies are thus being developed, targeting specific aspects of tumor growth. While histopathology remains the gold standard for tumor classification, neuroimaging has over the years taken a central role in the diagnosis and treatment follow up of brain tumors. It is used to detect and localize lesions, define the target area for biopsies, plan surgical and radiation interventions and assess tumor progression and treatment outcome. In recent years the application of novel drugs including anti-angiogenic agents that affect the tumor vasculature, has drastically modulated the outcome of brain tumor imaging. To properly evaluate the effects of emerging experimental therapies and successfully support treatment decisions, neuroimaging will have to evolve. Multi-modal imaging systems with existing and new contrast agents, molecular tracers, technological advances and advanced data analysis can all contribute to the establishment of disease relevant biomarkers that will improve disease management and patient care. In this review, we address the challenges of glioma imaging in the context of novel molecular and cellular therapies, and take a prospective look at emerging experimental and pre-clinical imaging techniques that bear the promise of meeting these challenges.
Key words
(11)C-methionine (PubChem CID: 15556483); (18)F-fluorodeoxyglucose (PubChem CID: 450503); (18)F-fluoroethyltyrosine (PubChem CID: 44439370); (18)F-fluoromisonidazole (PubChem CID: 450173); (18)F-fluorothymidine (PubChem CID: 450772); Brain tumors; Computer vision; Gadolinium (PubChem CID: 23982); Image analysis; Magnetic resonance imaging; Molecular imaging; Neuroimaging; Positron emission tomography; Radiology information systems; Temozolomide (PubChem CID: 5394)
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Multimodal Imaging
/
Glioma
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Adv Drug Deliv Rev
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2014
Document type:
Article