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Genome analysis of NDM-1 producing Morganella morganii clinical isolate.
Olaitan, Abiola Olumuyiwa; Diene, Seydina M; Gupta, Sushim Kumar; Adler, Amos; Assous, Marc Victor; Rolain, Jean-Marc.
Affiliation
  • Olaitan AO; Unité de recherche sur les maladies infectieuses et tropicales émergentes (URMITE) CNRS-IRD UMR 6236, Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France.
Expert Rev Anti Infect Ther ; 12(10): 1297-305, 2014 Oct.
Article in En | MEDLINE | ID: mdl-25081858
OBJECTIVE: To analyze the resistome and virulence genes of Morganella morganii F675, a multidrug-resistant clinical isolate using whole genome sequencing (WGS). METHODS: M. morganii F675 was isolated from a patient from Jerusalem, Israel. WGS was performed using both 454 and SOLiD sequencing technologies. Analyses of the bacterial resistome and other virulence genes were performed in addition to comparison with other available M. morganii genomes. RESULTS: The assembled sequence had a genome size of 4,127,528 bp with G+C content of 51%. The resistome consisted of 13 antibiotic resistance genes including blaNDM-1 located in a plasmid likely acquired from Acinetobacter spp. Moreover, we characterized for the first time the whole lipid A biosynthesis pathway in this species along with the O-antigen gene cluster, the urease gene cluster and several other virulence genes. CONCLUSION: The WGS analysis of this pathogen further provides insight into its pathogenicity and resistance to antibiotics.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Genome, Bacterial / Morganella morganii Language: En Journal: Expert Rev Anti Infect Ther Journal subject: DOENCAS TRANSMISSIVEIS Year: 2014 Document type: Article Affiliation country: France Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Genome, Bacterial / Morganella morganii Language: En Journal: Expert Rev Anti Infect Ther Journal subject: DOENCAS TRANSMISSIVEIS Year: 2014 Document type: Article Affiliation country: France Country of publication: United kingdom