p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8âº T cells.

Henson, Sian M; Lanna, Alessio; Riddell, Natalie E; Franzese, Ornella; Macaulay, Richard; Griffiths, Stephen J; Puleston, Daniel J; Watson, Alexander Scarth; Simon, Anna Katharina; Tooze, Sharon A; Akbar, Arne N

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8âº T cells.

Henson, Sian M; Lanna, Alessio; Riddell, Natalie E; Franzese, Ornella; Macaulay, Richard; Griffiths, Stephen J; Puleston, Daniel J; Watson, Alexander Scarth; Simon, Anna Katharina; Tooze, Sharon A; Akbar, Arne N.

J Clin Invest ; 124(9): 4004-16, 2014 Sep.

Article in En | MEDLINE | ID: mdl-25083993

Subject(s)

Autophagy/physiology; CD8-Positive T-Lymphocytes/physiology; MAP Kinase Signaling System/physiology; Multiprotein Complexes/physiology; TOR Serine-Threonine Kinases/physiology; p38 Mitogen-Activated Protein Kinases/physiology; Adult; Autophagy-Related Proteins; Cellular Senescence; DNA Damage; Glycolysis; Humans; Mechanistic Target of Rapamycin Complex 1; Membrane Potential, Mitochondrial; Membrane Proteins/physiology; Mitochondria/physiology; Oxidative Phosphorylation; Vesicular Transport Proteins/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / CD8-Positive T-Lymphocytes / MAP Kinase Signaling System / Multiprotein Complexes / P38 Mitogen-Activated Protein Kinases / TOR Serine-Threonine Kinases Limits: Adult / Humans Language: En Journal: J Clin Invest Year: 2014 Document type: Article Country of publication: United States

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