mTOR and autophagy in regulation of acute lung injury: a review and perspective.
Microbes Infect
; 16(9): 727-34, 2014 Sep.
Article
in En
| MEDLINE
| ID: mdl-25084494
ABSTRACT
The mammalian target of rapamycin (mTOR) is a central regulator of many major cellular processes including protein and lipid synthesis and autophagy, and is also implicated in an increasing number of pathological conditions. Emerging evidence suggests that both mTOR and autophagy are critically involved in the pathogenesis of pulmonary diseases including acute lung injury (ALI). However, the detailed mechanisms of these pathways in disease pathogenesis require further investigations. In certain cases within the same disease, the functions of mTOR and autophagy may vary from different cell types and pathogens. Here we review recent advances about the basic machinery of mTOR and autophagy, and their roles in ALI. We further discuss and propose the likelihood of cell type- and pathogen-dependent functions of these pathways in ALI pathogenesis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Acute Lung Injury
/
TOR Serine-Threonine Kinases
Limits:
Animals
/
Humans
Language:
En
Journal:
Microbes Infect
Journal subject:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
Year:
2014
Document type:
Article
Affiliation country:
China