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Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test.
Dupont, Benoît; Mariotte, Delphine; Moldovan, Cristian; Grellard, Jean-Michel; Vergnaud, Marie-Claude; Laroche, Dominique; Gervais, Radj.
Affiliation
  • Dupont B; CHU de Caen, Service d'Hépato-Gastroentérologie et Nutrition, Caen, France. ; Université de Caen Basse-Normandie, UFR Médecine, Caen, France.
  • Mariotte D; CHU de Caen, Laboratoire d'Immunologie et Immunopathologie, Caen, France.
  • Moldovan C; Centre Henri Becquerel; Oncologie Médicale, Rouen, France.
  • Grellard JM; Centre François Baclesse, Service de Recherche Clinique, Caen, France.
  • Vergnaud MC; CHU de Caen; Service de Médecine Polyvalente, Caen, France.
  • Laroche D; Université de Caen Basse-Normandie, UFR Médecine, Caen, France. ; CHU de Caen, Laboratoire d'Hormonologie, Caen, France.
  • Gervais R; Centre François Baclesse, Oncologie Médicale, Caen, France.
Clin Med Insights Oncol ; 8: 91-4, 2014.
Article in En | MEDLINE | ID: mdl-25089092
ABSTRACT
Hypersensitivity reactions are a classic side effect of cetuximab. We report the cases of three patients who developed life-threatening hypersensitivity to cetuximab, which could have been predicted by assessing the concentration of serum anticetuximab immunoglobulin (Ig)E. The anticetuximab IgE concentration could be an interesting test to predict which patients are at risk of experiencing severe hypersensitivity reactions to cetuximab.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Clin Med Insights Oncol Year: 2014 Document type: Article Affiliation country: France Country of publication: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Clin Med Insights Oncol Year: 2014 Document type: Article Affiliation country: France Country of publication: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA