Detection of PI3K inhibition in human neuroblastoma using multiplex luminex bead immunoassay: a targeted approach for pathway analysis.

Lang, Walter H; Sandoval, John A

Lang, Walter H; Sandoval, John A.

Affiliation

Lang WH; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sandoval JA; Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA john.sandoval@stjude.org.

J Biomol Screen ; 19(9): 1235-45, 2014 Oct.

Article in En | MEDLINE | ID: mdl-25092063

Subject(s)

Antineoplastic Agents/pharmacology; Drug Screening Assays, Antitumor; Immunoassay; Neuroblastoma/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction/drug effects; Antineoplastic Agents/toxicity; Cell Line, Tumor; Cell Survival/drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor/methods; Drug Synergism; Humans; Immunoassay/methods; Phosphoproteins; Phosphorylation/drug effects; Protein Kinase Inhibitors; Proteome; Proteomics; TOR Serine-Threonine Kinases/antagonists & inhibitors

Key words

IGF-1R/AKT/PI3k/mTOR pathway; PI3K inhibition; intracellular signaling screening; multiplex bead technology; neuroblastoma

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoassay / Drug Screening Assays, Antitumor / Signal Transduction / Phosphatidylinositol 3-Kinases / Phosphoinositide-3 Kinase Inhibitors / Neuroblastoma / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Biomol Screen Journal subject: BIOLOGIA MOLECULAR Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

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