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Refractive errors after the use of bevacizumab for the treatment of retinopathy of prematurity: 2-year outcomes.
Chen, Y-H; Chen, S-N; Lien, R-I; Shih, C-P; Chao, A-N; Chen, K-J; Hwang, Y-S; Wang, N-K; Chen, Y-P; Lee, K-H; Chuang, C-C; Chen, T-L; Lai, C-C; Wu, W-C.
Affiliation
  • Chen YH; 1] Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan [2] College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Chen SN; 1] Department of Ophthalmology, Chang-Hua Christian Hospital, Chang-Hua city, Taiwan [2] School of Medicine, Chung Shan Medical University.
  • Lien RI; 1] College of Medicine, Chang Gung University, Taoyuan, Taiwan [2] Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • Shih CP; Department of Business Administration, Chang Gung University, Taoyuan, Taiwan.
  • Chao AN; 1] Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan [2] College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Chen KJ; 1] Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan [2] College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Hwang YS; 1] Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan [2] College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Wang NK; 1] Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan [2] College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Chen YP; 1] Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan [2] College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Lee KH; Department of Ophthalmology, Chang-Hua Christian Hospital, Chang-Hua city, Taiwan.
  • Chuang CC; Department of Ophthalmology, Chang-Hua Christian Hospital, Chang-Hua city, Taiwan.
  • Chen TL; 1] Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan [2] College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Lai CC; 1] Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan [2] College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Wu WC; 1] Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan [2] College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Eye (Lond) ; 28(9): 1080-6; quiz 1087, 2014 Sep.
Article in En | MEDLINE | ID: mdl-25104736
PURPOSE: To evaluate the refractive outcomes in children treated after intravitreal injection of bevacizumab (IVB) for retinopathy of prematurity (ROP). METHODS: A retrospective, bi-centre study of 34 patients (64 eyes) was conducted. The patients were divided into three groups, patients received intravitreal IVB (IVB group), patients received combined IVB and laser treatment (IVB + Laser group), or patients received lens-sparing vitrectomy (IVB + LSV group). Cycloplegic refraction and axial length (AXL) were evaluated at 2 years old. RESULTS: The prevalences of myopia and high myopia were 47.5 and 10.0% in the IVB group, respectively, which were lower than those in the IVB + Laser (82.4 and 29.4%) and IVB + LSV (all 100%) groups (P = 0.001 and P < 0.001). The prevalences of emmetropia in the IVB group, IVB + Laser group, and IVB + LSV group were 50, 5.9, and 0% (P = 0.001). The AXL were similar among all groups. CONCLUSIONS: At the 2-year follow-up, severe ROP patients treated with IVB alone were more likely to remain emmetropic and had lower prevalences of myopia and high myopia. The development of high myopia in severe ROP patients could not be explained by AXL changes but may be associated with abnormalities in the anterior segment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinopathy of Prematurity / Angiogenesis Inhibitors / Antibodies, Monoclonal, Humanized / Myopia Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Child, preschool / Female / Humans / Male Language: En Journal: Eye (Lond) Journal subject: OFTALMOLOGIA Year: 2014 Document type: Article Affiliation country: Taiwan Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinopathy of Prematurity / Angiogenesis Inhibitors / Antibodies, Monoclonal, Humanized / Myopia Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Child, preschool / Female / Humans / Male Language: En Journal: Eye (Lond) Journal subject: OFTALMOLOGIA Year: 2014 Document type: Article Affiliation country: Taiwan Country of publication: United kingdom