A systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation.

Würstle, Maximilian L; Rehm, Markus

Würstle, Maximilian L; Rehm, Markus.

Affiliation

Würstle ML; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Rehm M; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland. Electronic address: mrehm@rcsi.ie.

J Biol Chem ; 289(38): 26277-26289, 2014 Sep 19.

Article in En | MEDLINE | ID: mdl-25107908

Subject(s)

Apoptosis; Apoptosomes/physiology; Caspase 9/physiology; Protein Precursors/physiology; Allosteric Regulation; Apoptosomes/chemistry; Apoptotic Protease-Activating Factor 1/chemistry; Apoptotic Protease-Activating Factor 1/physiology; Caspase 9/chemistry; Catalytic Domain; Computer Simulation; Enzyme Activation; HeLa Cells; Humans; Kinetics; Models, Molecular; Protein Binding; Protein Multimerization; Protein Precursors/chemistry; Systems Biology

Key words

Apaf-1; Apoptosis; Apoptosome; Caspase; Caspase-3; Caspase-9; Cell Death; Computational Biology; Systems Biology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Precursors / Apoptosis / Apoptosomes / Caspase 9 Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2014 Document type: Article Affiliation country: Ireland Country of publication: United States

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