Understanding and reducing the experimental variability of in vitro plasma protein binding measurements.

Wang, Haiping; Zrada, Matt; Anderson, Ken; Katwaru, Ravi; Harradine, Paul; Choi, Bernard; Tong, Vince; Pajkovic, Natasa; Mazenko, Ralph; Cox, Kathy; Cohen, Lucinda H

Wang, Haiping; Zrada, Matt; Anderson, Ken; Katwaru, Ravi; Harradine, Paul; Choi, Bernard; Tong, Vince; Pajkovic, Natasa; Mazenko, Ralph; Cox, Kathy; Cohen, Lucinda H.

Affiliation

Wang H; Department of Pharmacodynamics, Pharmacokinetics and Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey.

J Pharm Sci ; 103(10): 3302-9, 2014 Oct.

Article in En | MEDLINE | ID: mdl-25116691

Subject(s)

Blood Proteins/metabolism; Chromatography, Liquid; Humans; Hydrogen-Ion Concentration; Mass Spectrometry; Protein Binding

Key words

HPLC; equilibrium dialysis; mass spectrometry; preclinical pharmacokinetics; protein binding; robotics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Proteins Type of study: Guideline / Prognostic_studies Limits: Humans Language: En Journal: J Pharm Sci Year: 2014 Document type: Article Country of publication: United States

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