Activation of JNK/p38 pathway is responsible for &#945;-methyl-n-butylshikonin induced mitochondria-dependent apoptosis in SW620 human colorectal cancer cells.

Wang, Hai-Bing; Ma, Xiao-Qiong

Activation of JNK/p38 pathway is responsible for α-methyl-n-butylshikonin induced mitochondria-dependent apoptosis in SW620 human colorectal cancer cells.

Wang, Hai-Bing; Ma, Xiao-Qiong.

Affiliation

Wang HB; National Clinical Research Base of Traditional Chinese Medicine, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Hangzhou, China E-mail : wanghaibing221@126.com.

Asian Pac J Cancer Prev ; 15(15): 6321-6, 2014.

Article in En | MEDLINE | ID: mdl-25124618

Subject(s)

Apoptosis/drug effects; Colorectal Neoplasms/pathology; JNK Mitogen-Activated Protein Kinases/metabolism; Mitochondria/drug effects; Naphthoquinones/pharmacology; p38 Mitogen-Activated Protein Kinases/metabolism; Blotting, Western; Caspases/metabolism; Cell Proliferation/drug effects; Colorectal Neoplasms/drug therapy; Colorectal Neoplasms/metabolism; Cytochromes c/metabolism; Humans; Membrane Potential, Mitochondrial/drug effects; Mitochondria/metabolism; Molecular Structure; Naphthoquinones/chemistry; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Naphthoquinones / Apoptosis / JNK Mitogen-Activated Protein Kinases / P38 Mitogen-Activated Protein Kinases / Mitochondria Limits: Humans Language: En Journal: Asian Pac J Cancer Prev Journal subject: NEOPLASIAS Year: 2014 Document type: Article Country of publication: Thailand

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