Propylene cross-bridged macrocyclic bifunctional chelator: a new design for facile bioconjugation and robust (64)Cu complex stability.

Pandya, Darpan N; Bhatt, Nikunj; An, Gwang Il; Ha, Yeong Su; Soni, Nisarg; Lee, Hochun; Lee, Yong Jin; Kim, Jung Young; Lee, Woonghee; Ahn, Heesu; Yoo, Jeongsoo

Pandya, Darpan N; Bhatt, Nikunj; An, Gwang Il; Ha, Yeong Su; Soni, Nisarg; Lee, Hochun; Lee, Yong Jin; Kim, Jung Young; Lee, Woonghee; Ahn, Heesu; Yoo, Jeongsoo.

Affiliation

Pandya DN; Department of Molecular Medicine, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University , Daegu 700-422, South Korea.

J Med Chem ; 57(17): 7234-43, 2014 Sep 11.

Article in En | MEDLINE | ID: mdl-25137619

Subject(s)

Alkenes/chemistry; Chelating Agents/chemistry; Copper/chemistry; Drug Design; Macrocyclic Compounds/chemistry; Animals; Chelating Agents/chemical synthesis; Chelating Agents/pharmacokinetics; Coordination Complexes/chemistry; Copper Radioisotopes/chemistry; Copper Radioisotopes/pharmacokinetics; Glioblastoma/metabolism; Glioblastoma/pathology; Heterocyclic Compounds/chemistry; Humans; Macrocyclic Compounds/chemical synthesis; Mice; Mice, Nude; Models, Chemical; Molecular Structure; Oligopeptides/chemistry; Positron-Emission Tomography/methods; Rats; Tissue Distribution; Transplantation, Heterologous

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Chelating Agents / Copper / Macrocyclic Compounds / Alkenes Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country: South Korea

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