Organophosphorus pesticide chlorpyrifos and its metabolites alter the expression of biomarker genes of differentiation in D3 mouse embryonic stem cells in a comparable way to other model neurodevelopmental toxicants.

Estevan, Carmen; Fuster, Encarnación; Del Río, Eva; Pamies, David; Vilanova, Eugenio; Sogorb, Miguel A

Estevan, Carmen; Fuster, Encarnación; Del Río, Eva; Pamies, David; Vilanova, Eugenio; Sogorb, Miguel A.

Affiliation

Estevan C; Unidad de Toxicología y Seguridad Química, Instituto de Bioingeniería, Universidad Miguel Hernández de Elche , Avenida de la Universidad s/n, 03202-Elche, Spain.

Chem Res Toxicol ; 27(9): 1487-95, 2014 Sep 15.

Article in En | MEDLINE | ID: mdl-25137620

Subject(s)

Cell Differentiation/drug effects; Chlorpyrifos/toxicity; Embryonic Stem Cells/drug effects; Pesticides/toxicity; Animals; Biomarkers/metabolism; Cell Survival/drug effects; Cells, Cultured; Chlorpyrifos/metabolism; Embryonic Stem Cells/cytology; Embryonic Stem Cells/metabolism; Gene Expression Regulation/drug effects; Mice; Neurogenesis/drug effects; Organophosphorus Compounds/toxicity; Penicillin G/toxicity; Tretinoin/toxicity; Valproic Acid/toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pesticides / Cell Differentiation / Chlorpyrifos / Embryonic Stem Cells Limits: Animals Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2014 Document type: Article Affiliation country: Spain Country of publication: United States

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