Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age.
Brain Res
; 503(2): 334-8, 1989 Dec 04.
Article
in En
| MEDLINE
| ID: mdl-2514009
ABSTRACT
Golgi-impregnated medium-size spiny neurones were studied in the rat neostriatum at various times after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle. At both short (12-26 days) and long (7-12 months) survival times, the density of spines was significantly lower (13%) on neostriatal neurones ipsilateral to the 6-hydroxydopamine injection. At longer times the density of spines was lower on neurones both ipsilateral and contralateral to the lesion when compared to neurones taken from short-term animals (23%).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Corpus Striatum
/
Dendrites
/
Hydroxydopamines
/
Medial Forebrain Bundle
Limits:
Animals
Language:
En
Journal:
Brain Res
Year:
1989
Document type:
Article
Affiliation country:
United kingdom