Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes.
Pharmacogenomics
; 15(10): 1311-21, 2014 Jul.
Article
in En
| MEDLINE
| ID: mdl-25155933
ABSTRACT
AIM:
Familial loading for alcohol dependence (AD) and variation in genes reported to be associated with AD or BMI were tested in a longitudinal study. MATERIALS &METHODS:
Growth curve analyses of BMI data collected at approximately yearly intervals and obesity status (BMI > 30) were examined.RESULTS:
High-risk males were found to have higher BMI than low-risk males, beginning at age 15 years (2.0 kg/m(2) difference; p = 0.046), persisting through age 19 years (3.3 kg/m(2) difference; p = 0.005). CHRM2 genotypic variance predicted longitudinal BMI and obesity status. Interactions with risk status and sex were also observed for DRD2 and FTO gene variation.CONCLUSION:
Variation at loci implicated in addiction may be influential in determining susceptibility to increased BMI in childhood and adolescence.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Body Mass Index
/
Genetic Predisposition to Disease
/
Alcoholism
/
Obesity
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Pharmacogenomics
Journal subject:
FARMACOLOGIA
/
GENETICA MEDICA
Year:
2014
Document type:
Article
Affiliation country:
United States