Naltrexone attenuates endoplasmic reticulum stress induced hepatic injury in mice.

Moslehi, A; Nabavizadeh, F; Nabavizadeh, Fatemeh; Dehpour, A R; Dehpou, A R; Tavanga, S M; Hassanzadeh, G; Zekri, A; Nahrevanian, H; Sohanaki, H

Moslehi, A; Nabavizadeh, F; Nabavizadeh, Fatemeh; Dehpour, A R; Dehpou, A R; Tavanga, S M; Hassanzadeh, G; Zekri, A; Nahrevanian, H; Sohanaki, H.

Affiliation

Moslehi A; Tehran University of Medical Sciences Department of Physiology, School of Medicine Tehran 1417613151 Iran.
Nabavizadeh F; Tehran University of Medical Sciences Department of Physiology, School of Medicine Tehran 1417613151 Iran.
Dehpou AR; Tehran University of Medical Sciences Department of Pharmacology, School of Medicine Tehran Iran.
Tavanga SM; Tehran University of Medical Sciences Shariati Hospital Tehran Iran.
Hassanzadeh G; Tehran University of Medical Sciences Department of Anatomy, School of Medicine Tehran Iran.
Zekri A; Tehran University of Medical Sciences Department of Genetics, School of Medicine Tehran Iran.
Nahrevanian H; Pasteur Institute of Iran Department of Parasitology Tehran Iran.
Sohanaki H; Iran University of Medical Sciences Department of Physiology, School of Medicine Tehran Iran.

Acta Physiol Hung ; 101(3): 341-52, 2014 Sep.

Article in En | MEDLINE | ID: mdl-25183508

Subject(s)

Chemical and Drug Induced Liver Injury/prevention & control; Endoplasmic Reticulum Stress/drug effects; Endoplasmic Reticulum/drug effects; Fatty Liver/prevention & control; Liver/drug effects; Naltrexone/pharmacology; Narcotic Antagonists/pharmacology; Alanine Transaminase/blood; Animals; Anti-Inflammatory Agents/pharmacology; Aspartate Aminotransferases/blood; Biomarkers/blood; Caspase 3/metabolism; Chemical and Drug Induced Liver Injury/etiology; Chemical and Drug Induced Liver Injury/metabolism; Chemical and Drug Induced Liver Injury/pathology; Chemical and Drug Induced Liver Injury/physiopathology; Cholesterol/blood; Cytoprotection; Disease Models, Animal; Endoplasmic Reticulum/metabolism; Endoplasmic Reticulum/pathology; Fatty Liver/chemically induced; Fatty Liver/metabolism; Fatty Liver/pathology; Fatty Liver/physiopathology; Liver/blood supply; Liver/metabolism; Liver/pathology; Liver Circulation/drug effects; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proto-Oncogene Proteins c-bcl-2/metabolism; Triglycerides/blood; Tumor Necrosis Factor-alpha/blood; Tunicamycin; bcl-2-Associated X Protein/metabolism

Key words

endoplasmic reticulum stress; liver; naltrexone; steatosis; tunicamycin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endoplasmic Reticulum / Fatty Liver / Chemical and Drug Induced Liver Injury / Endoplasmic Reticulum Stress / Liver / Naltrexone / Narcotic Antagonists Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Acta Physiol Hung Year: 2014 Document type: Article Country of publication: Hungary

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