Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function.

Bassi, M; Nakamura, N B; Furuya, W I; Colombari, D S A; Menani, J V; do Carmo, J M; da Silva, A A; Hall, J E; Colombari, E

Bassi, M; Nakamura, N B; Furuya, W I; Colombari, D S A; Menani, J V; do Carmo, J M; da Silva, A A; Hall, J E; Colombari, E.

Affiliation

Bassi M; Department of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.

Acta Physiol (Oxf) ; 213(4): 893-901, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25207799

Subject(s)

Leptin/pharmacology; Melanocortins/metabolism; Melanocyte-Stimulating Hormones/pharmacology; Receptor, Melanocortin, Type 3/metabolism; Receptor, Melanocortin, Type 4/metabolism; Respiratory Physiological Phenomena/drug effects; Animals; Body Weight/drug effects; Carbon Dioxide/blood; Gene Expression Regulation; Hypercapnia/chemically induced; Leptin/administration & dosage; Male; Melanocyte-Stimulating Hormones/administration & dosage; Mice; Mice, Knockout; Rats; Rats, Sprague-Dawley; Receptor, Melanocortin, Type 3/genetics; Receptor, Melanocortin, Type 4/genetics

Key words

MC3/4 receptor; blood pressure; central chemoreception; hypercapnia; leptin; melanocortin system

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Physiological Phenomena / Melanocyte-Stimulating Hormones / Leptin / Receptor, Melanocortin, Type 3 / Receptor, Melanocortin, Type 4 / Melanocortins Limits: Animals Language: En Journal: Acta Physiol (Oxf) Journal subject: FISIOLOGIA Year: 2015 Document type: Article Affiliation country: Brazil Country of publication: United kingdom

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