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Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013.
Rith, Sareth; Davis, C Todd; Duong, Veasna; Sar, Borann; Horm, Srey Viseth; Chin, Savuth; Ly, Sovann; Laurent, Denis; Richner, Beat; Oboho, Ikwo; Jang, Yunho; Davis, William; Thor, Sharmi; Balish, Amanda; Iuliano, A Danielle; Sorn, San; Holl, Davun; Sok, Touch; Seng, Heng; Tarantola, Arnaud; Tsuyuoka, Reiko; Parry, Amy; Chea, Nora; Allal, Lotfi; Kitsutani, Paul; Warren, Dora; Prouty, Michael; Horwood, Paul; Widdowson, Marc-Alain; Lindstrom, Stephen; Villanueva, Julie; Donis, Ruben; Cox, Nancy; Buchy, Philippe.
Affiliation
  • Rith S; Virology Unit/National Influenza Centre, Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
  • Davis CT; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Duong V; Virology Unit/National Influenza Centre, Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
  • Sar B; Centers for Disease Control and Prevention, Atlanta, Georgia, USA Centers for Disease Control and Prevention, Phnom Penh, Cambodia.
  • Horm SV; Virology Unit/National Influenza Centre, Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
  • Chin S; National Institute of Public Health, Phnom Penh, Cambodia.
  • Ly S; Communicable Disease Department, Ministry of Health, Phnom Penh, Cambodia.
  • Laurent D; Kantha Bopha Hospital, Phnom Penh, Cambodia.
  • Richner B; Kantha Bopha Hospital, Phnom Penh, Cambodia.
  • Oboho I; Centers for Disease Control and Prevention, Atlanta, Georgia, USA Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Jang Y; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Davis W; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Thor S; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Balish A; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Iuliano AD; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Sorn S; National Veterinary Research Institute, Ministry of Agriculture, Forestry and Fisheries, Phnom Penh, Cambodia.
  • Holl D; National Veterinary Research Institute, Ministry of Agriculture, Forestry and Fisheries, Phnom Penh, Cambodia.
  • Sok T; Communicable Disease Department, Ministry of Health, Phnom Penh, Cambodia.
  • Seng H; Communicable Disease Department, Ministry of Health, Phnom Penh, Cambodia.
  • Tarantola A; Virology Unit/National Influenza Centre, Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
  • Tsuyuoka R; World Health Organization, Phnom Penh, Cambodia.
  • Parry A; World Health Organization, Phnom Penh, Cambodia.
  • Chea N; World Health Organization, Phnom Penh, Cambodia.
  • Allal L; Food and Agriculture Organization, Phnom Penh, Cambodia.
  • Kitsutani P; Centers for Disease Control and Prevention, Atlanta, Georgia, USA Centers for Disease Control and Prevention, Phnom Penh, Cambodia.
  • Warren D; Centers for Disease Control and Prevention, Atlanta, Georgia, USA Centers for Disease Control and Prevention, Phnom Penh, Cambodia.
  • Prouty M; U.S. Naval Medical Research Unit No. 2, Phnom Penh, Cambodia.
  • Horwood P; Virology Unit/National Influenza Centre, Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
  • Widdowson MA; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Lindstrom S; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Villanueva J; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Donis R; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Cox N; Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Buchy P; Virology Unit/National Influenza Centre, Institut Pasteur in Cambodia, Phnom Penh, Cambodia buchyphilippe@hotmail.com.
J Virol ; 88(23): 13897-909, 2014 Dec.
Article in En | MEDLINE | ID: mdl-25210193
ABSTRACT
Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Markers / Influenza, Human / Influenza A Virus, H5N1 Subtype / Virus Attachment Type of study: Diagnostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Virol Year: 2014 Document type: Article Affiliation country: Cambodia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Markers / Influenza, Human / Influenza A Virus, H5N1 Subtype / Virus Attachment Type of study: Diagnostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Virol Year: 2014 Document type: Article Affiliation country: Cambodia