Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013.
J Virol
; 88(23): 13897-909, 2014 Dec.
Article
in En
| MEDLINE
| ID: mdl-25210193
ABSTRACT
Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Markers
/
Influenza, Human
/
Influenza A Virus, H5N1 Subtype
/
Virus Attachment
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Virol
Year:
2014
Document type:
Article
Affiliation country:
Cambodia