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ALCAM and CD6--multiple sclerosis risk factors.
Wagner, M; Bilinska, M; Pokryszko-Dragan, A; Sobczynski, M; Cyrul, M; Kusnierczyk, P; Jasek, M.
Affiliation
  • Wagner M; Laboratory of Immunogenetics and Tissue Immunology, Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Ul. Weigla 12, 53-114 Wroclaw, Poland. Electronic address: marta_wagner@o2.pl.
  • Bilinska M; Department and Clinic of Neurology, Wroclaw Medical University, Ul. Borowska 213, 50-566 Wroclaw, Poland.
  • Pokryszko-Dragan A; Department and Clinic of Neurology, Wroclaw Medical University, Ul. Borowska 213, 50-566 Wroclaw, Poland.
  • Sobczynski M; Department of Genomics, Faculty of Biotechnology, University of Wroclaw, Ul. Fryderyka Joliot-Curie 14a, 50-383 Wroclaw, Poland.
  • Cyrul M; Department and Clinic of Neurology, Wroclaw Medical University, Ul. Borowska 213, 50-566 Wroclaw, Poland.
  • Kusnierczyk P; Laboratory of Immunogenetics and Tissue Immunology, Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Ul. Weigla 12, 53-114 Wroclaw, Poland.
  • Jasek M; Laboratory of Immunogenetics and Tissue Immunology, Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Ul. Weigla 12, 53-114 Wroclaw, Poland. Electronic address: jasek@iitd.pan.wroc.pl.
J Neuroimmunol ; 276(1-2): 98-103, 2014 Nov 15.
Article in En | MEDLINE | ID: mdl-25216742
ABSTRACT
ALCAM and CD6 may play an important role in the pathogenesis of multiple sclerosis (MS), since they are involved in the transmigration of leukocytes across the blood-brain barrier. In this study, we confirmed our previous findings about the association of the ALCAM gene with risk, development and progression of MS. Additionally, we showed that in the case of the CD6 gene (encoding receptor of ALCAM) not only polymorphisms but also mRNA expression level are associated with MS. Our analysis revealed that the risk of the disease for AA individuals in rs12360861 was almost 3.0-fold lower in comparison to GG individuals (OR=0.34; CI95%=0.12; 0.81). Moreover, we observed lower expression of CD6 mRNA in patients than in healthy individuals (T(2)2,74=6.678; p=0.002).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antigens, Differentiation, T-Lymphocyte / Antigens, CD / Cell Adhesion Molecules, Neuronal / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Fetal Proteins / Multiple Sclerosis Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Neuroimmunol Year: 2014 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antigens, Differentiation, T-Lymphocyte / Antigens, CD / Cell Adhesion Molecules, Neuronal / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Fetal Proteins / Multiple Sclerosis Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Neuroimmunol Year: 2014 Document type: Article