Recent developments linking retroviruses to human breast cancer: infectious agent, enemy within or both?
J Gen Virol
; 95(Pt 12): 2589-2593, 2014 Dec.
Article
in En
| MEDLINE
| ID: mdl-25217613
ABSTRACT
Evidence is accumulating that one or more beta-retrovirus is associated with human breast cancer. Retroviruses can exist as an infectious (exogenous) virus or as a part of the genetic information of cells due to germline integration (endogenous). An exogenous virus with a genome that is highly homologous to mouse mammary tumour virus is gaining acceptance as possibly being associated with human breast cancer, and recently furnished evidence is discussed in this article, as is the evidence for involvement of an endogenous human beta-retrovirus, HERV-K. Modes of interaction are also reviewed and linkages to the APOBEC3 family are suggested.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Retroviridae Infections
/
Endogenous Retroviruses
Limits:
Female
/
Humans
Language:
En
Journal:
J Gen Virol
Year:
2014
Document type:
Article
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM