Photolytic degradation products of two highly brominated flame retardants cause cytotoxicity and mRNA expression alterations in chicken embryonic hepatocytes.

Su, Guanyong; Letcher, Robert J; Crump, Doug; Farmahin, Reza; Giesy, John P; Kennedy, Sean W

Su, Guanyong; Letcher, Robert J; Crump, Doug; Farmahin, Reza; Giesy, John P; Kennedy, Sean W.

Affiliation

Su G; Ecotoxicology and Wildlife Health Division, Environment Canada, National Wildlife Research Centre, Carleton University , Ottawa, Ontario K1A 0H3, Canada.

Environ Sci Technol ; 48(20): 12039-46, 2014 Oct 21.

Article in En | MEDLINE | ID: mdl-25222814

Subject(s)

Bromobenzenes/toxicity; Flame Retardants/toxicity; Gene Expression Regulation/drug effects; Halogenated Diphenyl Ethers/toxicity; Hepatocytes/drug effects; Phenyl Ethers/toxicity; Animals; Bromobenzenes/metabolism; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Female; Flame Retardants/metabolism; Halogenated Diphenyl Ethers/metabolism; Halogenation; Hepatocytes/metabolism; Phenyl Ethers/metabolism; Photolysis; Polymerase Chain Reaction; RNA, Messenger; Receptors, Aryl Hydrocarbon/metabolism; Sunlight; Toxicity Tests/methods

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenyl Ethers / Bromobenzenes / Gene Expression Regulation / Hepatocytes / Halogenated Diphenyl Ethers / Flame Retardants Limits: Animals Language: En Journal: Environ Sci Technol Year: 2014 Document type: Article Affiliation country: Canada Country of publication: United States

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