Synthesis of novel phosphonic-type activity-based probes for neutrophil serine proteases and their application in spleen lysates of different organisms.

Grzywa, Renata; Burchacka, Ewa; Lecka, Maria; Winiarski, Lukasz; Walczak, Maciej; Lupicka-Slowik, Agnieszka; Wysocka, Magdalena; Burster, Timo; Bobrek, Kamila; Csencsits-Smith, Keri; Lesner, Adam; Sienczyk, Marcin

Grzywa, Renata; Burchacka, Ewa; Lecka, Maria; Winiarski, Lukasz; Walczak, Maciej; Lupicka-Slowik, Agnieszka; Wysocka, Magdalena; Burster, Timo; Bobrek, Kamila; Csencsits-Smith, Keri; Lesner, Adam; Sienczyk, Marcin.

Affiliation

Grzywa R; Division Of Medicinal Chemistry and Microbiology, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw (Poland).

Chembiochem ; 15(17): 2605-12, 2014 Nov 24.

Article in En | MEDLINE | ID: mdl-25236966

Subject(s)

Molecular Probes/pharmacology; Neutrophils/enzymology; Phosphorous Acids/pharmacology; Protein Kinase Inhibitors/pharmacology; Serine Proteases/metabolism; Spleen/chemistry; Tissue Extracts; Humans; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/enzymology; Microscopy, Fluorescence; Molecular Docking Simulation; Molecular Probes/chemical synthesis; Molecular Probes/chemistry; Molecular Structure; Molecular Weight; Phosphorous Acids/chemical synthesis; Phosphorous Acids/chemistry; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/chemistry; Spleen/enzymology

Key words

activity-based probes; aminophosphonates; inhibitors; neutrophil serine proteases; peptidomimetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphorous Acids / Spleen / Tissue Extracts / Molecular Probes / Protein Kinase Inhibitors / Serine Proteases / Neutrophils Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2014 Document type: Article Country of publication: Germany

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