Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia.

Schwarzer, A; Holtmann, H; Brugman, M; Meyer, J; Schauerte, C; Zuber, J; Steinemann, D; Schlegelberger, B; Li, Z; Baum, C

Schwarzer, A; Holtmann, H; Brugman, M; Meyer, J; Schauerte, C; Zuber, J; Steinemann, D; Schlegelberger, B; Li, Z; Baum, C.

Affiliation

Schwarzer A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Holtmann H; Institute of Biochemistry, Hannover Medical School, Hannover, Germany.
Brugman M; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Meyer J; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Schauerte C; Institute of Biochemistry, Hannover Medical School, Hannover, Germany.
Zuber J; Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, Vienna, Austria.
Steinemann D; Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.
Schlegelberger B; Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.
Li Z; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Baum C; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.

Oncogene ; 34(27): 3593-604, 2015 Jul.

Article in En | MEDLINE | ID: mdl-25241901

Subject(s)

Eukaryotic Initiation Factor-4E/physiology; Leukemia, T-Cell/genetics; Leukemia, T-Cell/metabolism; Multiprotein Complexes/metabolism; Protein Biosynthesis; TOR Serine-Threonine Kinases/metabolism; Animals; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/metabolism; Gene Expression Regulation, Leukemic; Humans; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Biosynthesis/genetics; Signal Transduction; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Biosynthesis / Leukemia, T-Cell / Eukaryotic Initiation Factor-4E / Multiprotein Complexes / TOR Serine-Threonine Kinases Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2015 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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