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Bioactive depsidones from the fungus Pilobolus heterosporus.
Rajachan, Oue-artorn; Kanokmedhakul, Somdej; Kanokmedhakul, Kwanjai; Soytong, Kasem.
Affiliation
  • Rajachan OA; Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Kanokmedhakul S; Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Kanokmedhakul K; Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Soytong K; Department of Plant Production Technology, Faculty of Agricultural Technology, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
Planta Med ; 80(17): 1635-40, 2014 Nov.
Article in En | MEDLINE | ID: mdl-25248047
ABSTRACT
A new aromatic ester, pilobolusate (1), four new depsidones, pilobolusones A-D (2-5), five known depsidones, (6-10), and ergosterol were isolated from the fungus Pilobolus heterosporus. Their structures were established on the basis of spectroscopic data. Compounds 2 and 4-9 showed cytotoxicity against three cancer cell lines (KB, MCF-7, and NCI-H187) with IC50 values in the range of 9.94-97.42 µM. In addition, compounds 2, 5, 9, and 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values ranging from 3.67-23.56 µM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Depsides / Lactones / Mucorales / Antimalarials Limits: Animals Language: En Journal: Planta Med Year: 2014 Document type: Article Affiliation country: Thailand
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Depsides / Lactones / Mucorales / Antimalarials Limits: Animals Language: En Journal: Planta Med Year: 2014 Document type: Article Affiliation country: Thailand