Your browser doesn't support javascript.
loading
An adult B-cell precursor acute lymphoblastic leukemia with multiple secondary cytogenetic aberrations.
Al-Achkar, Walid; Wafa, Abdulsamad; Othman, Moneeb Abdullah Kassem; Moassass, Faten; Aljapawe, Abdulmunim; Liehr, Thomas.
Affiliation
  • Al-Achkar W; Department of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.
  • Wafa A; Department of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.
  • Othman MA; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
  • Moassass F; Department of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission of Syria, P.O. Box 6091, Damascus, Syria.
  • Aljapawe A; Department of Molecular Biology and Biotechnology, Mammalians Biology Division, Atomic Energy Commission, Damascus, Syria.
  • Liehr T; Institute of Human Genetics, Jena University Hospital, Jena, Germany.
Mol Cytogenet ; 7(1): 60, 2014.
Article in En | MEDLINE | ID: mdl-25254075
BACKGROUND: We report a clinically diagnosed acute lymphoblastic leukemia (ALL) with yet unreported secondary chromosomal aberrations. RESULTS: A complete cytogenetic and molecular cytogenetic analysis, using GTG banding, fluorescence in situ hybridization (FISH) and array-proven multicolor banding (aMCB), for a female patient with clinically diagnosed ALL and immunophenotypically confirmed pre-B ALL (FAB classifications), revealed the presence of a complex structural rearrangement, der (2) (20qter- > 20q13.33::2q21- > 2p14::2q21 > 2qter) along with t (9;22) (q34;q11), t (12;14) (q12;p12) and a monosomy of chromosome 7. CONCLUSIONS: Molecular cytogenetic studies are suited best for identification and characterization of chromosomal rearrangements in acute leukemia. Single case reports as well as large scale studies are necessary to provide further insights in karyotypic changes taking place in human malignancies.
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Mol Cytogenet Year: 2014 Document type: Article Affiliation country: Syria Country of publication: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Mol Cytogenet Year: 2014 Document type: Article Affiliation country: Syria Country of publication: United kingdom