Inhibition of monoacylglycerol lipase reduces nicotine withdrawal.

Muldoon, P P; Chen, J; Harenza, J L; Abdullah, R A; Sim-Selley, L J; Cravatt, B F; Miles, M F; Chen, X; Lichtman, A H; Damaj, M I

Muldoon, P P; Chen, J; Harenza, J L; Abdullah, R A; Sim-Selley, L J; Cravatt, B F; Miles, M F; Chen, X; Lichtman, A H; Damaj, M I.

Affiliation

Muldoon PP; Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.

Br J Pharmacol ; 172(3): 869-82, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25258021

Subject(s)

Benzodioxoles/pharmacology; Enzyme Inhibitors/pharmacology; Monoacylglycerol Lipases/antagonists & inhibitors; Nicotine/antagonists & inhibitors; Piperidines/pharmacology; Substance Withdrawal Syndrome/drug therapy; Animals; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Monoacylglycerol Lipases/deficiency; Monoacylglycerol Lipases/metabolism; Nicotine/administration & dosage; RNA, Messenger/drug effects; RNA, Messenger/genetics; RNA, Messenger/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Substance Withdrawal Syndrome / Enzyme Inhibitors / Benzodioxoles / Monoacylglycerol Lipases / Nicotine Limits: Animals Language: En Journal: Br J Pharmacol Year: 2015 Document type: Article Affiliation country: United States

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