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HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Swerdlow, Daniel I; Preiss, David; Kuchenbaecker, Karoline B; Holmes, Michael V; Engmann, Jorgen E L; Shah, Tina; Sofat, Reecha; Stender, Stefan; Johnson, Paul C D; Scott, Robert A; Leusink, Maarten; Verweij, Niek; Sharp, Stephen J; Guo, Yiran; Giambartolomei, Claudia; Chung, Christina; Peasey, Anne; Amuzu, Antoinette; Li, KaWah; Palmen, Jutta; Howard, Philip; Cooper, Jackie A; Drenos, Fotios; Li, Yun R; Lowe, Gordon; Gallacher, John; Stewart, Marlene C W; Tzoulaki, Ioanna; Buxbaum, Sarah G; van der A, Daphne L; Forouhi, Nita G; Onland-Moret, N Charlotte; van der Schouw, Yvonne T; Schnabel, Renate B; Hubacek, Jaroslav A; Kubinova, Ruzena; Baceviciene, Migle; Tamosiunas, Abdonas; Pajak, Andrzej; Topor-Madry, Roman; Stepaniak, Urszula; Malyutina, Sofia; Baldassarre, Damiano; Sennblad, Bengt; Tremoli, Elena; de Faire, Ulf; Veglia, Fabrizio; Ford, Ian; Jukema, J Wouter; Westendorp, Rudi G J.
Affiliation
  • Swerdlow DI; UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK. Electronic address: d.swerdlow@ucl.ac.uk.
  • Preiss D; BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. Electronic address: david.preiss@glasgow.ac.uk.
  • Kuchenbaecker KB; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Department of Surgery, Division of Transplantation, and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, Universit
  • Holmes MV; UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.
  • Engmann JE; UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.
  • Shah T; UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK.
  • Sofat R; UCL Department of Medicine, University College London, London, UK.
  • Stender S; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Johnson PC; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
  • Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
  • Leusink M; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.
  • Verweij N; University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands.
  • Sharp SJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
  • Guo Y; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Giambartolomei C; UCL Genetics Institute, University College London, London, UK.
  • Chung C; UCL Research Department of Epidemiology and Public Health, University College London, London, UK.
  • Peasey A; UCL Research Department of Epidemiology and Public Health, University College London, London, UK.
  • Amuzu A; London School of Hygiene & Tropical Medicine, London, UK.
  • Li K; Centre for Cardiovascular Genetics, University College London, London, UK.
  • Palmen J; Centre for Cardiovascular Genetics, University College London, London, UK.
  • Howard P; Centre for Cardiovascular Genetics, University College London, London, UK.
  • Cooper JA; Centre for Cardiovascular Genetics, University College London, London, UK.
  • Drenos F; Centre for Cardiovascular Genetics, University College London, London, UK.
  • Li YR; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Lowe G; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Gallacher J; Department of Primary Care and Public Health, Cardiff University Medical School, Cardiff University, Cardiff, UK.
  • Stewart MC; Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
  • Tzoulaki I; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Buxbaum SG; Jackson State University, Jackson, MS, USA.
  • van der A DL; National Institute for Public Health and the Environment, Bilthoven, Netherlands.
  • Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
  • Onland-Moret NC; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
  • van der Schouw YT; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
  • Schnabel RB; University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany.
  • Hubacek JA; Centre for Experimental Medicine, Institute of Clinical and Experimental Medicine, Prague, Czech Republic.
  • Kubinova R; National Institute of Public Health, Prague, Czech Republic.
  • Baceviciene M; Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Tamosiunas A; Institute of Cardiology, Kaunas, Lithuania.
  • Pajak A; Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
  • Topor-Madry R; Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
  • Stepaniak U; Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
  • Malyutina S; Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.
  • Baldassarre D; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy; Centro Cardiologico Monzino IRCCS Milan, Milan, Italy.
  • Sennblad B; Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
  • Tremoli E; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy; Centro Cardiologico Monzino IRCCS Milan, Milan, Italy.
  • de Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Veglia F; Biostatistics Unit, Milan, Italy.
  • Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
  • Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.
  • Westendorp RG; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands.
Lancet ; 385(9965): 351-61, 2015 Jan 24.
Article in En | MEDLINE | ID: mdl-25262344
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Body Weight / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Polymorphism, Single Nucleotide / Diabetes Mellitus, Type 2 / Hydroxymethylglutaryl CoA Reductases Type of study: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Lancet Year: 2015 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Body Weight / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Polymorphism, Single Nucleotide / Diabetes Mellitus, Type 2 / Hydroxymethylglutaryl CoA Reductases Type of study: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Lancet Year: 2015 Document type: Article Country of publication: United kingdom